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MDM2-p53 antagonist (BI 907828): mechanism of action
2:21
YouTubeOncology
MDM2-p53 antagonist (BI 907828): mechanism of action
BI 907828 is small molecule inhibiting the interaction between murine double minute 2 (MDM2) and p53. MDM2 is a negative regulator of the tumour suppressor p53. BI 907828 blocks the interaction between MDM2 and p53 by binding to free MDM2. This reactivates p53 tumour suppressor function and induction of target gene expression, leading to cell ...
5K viewsOct 13, 2020
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