Gut

Loss of sinusoidal endothelial identity: RAP1A at the crossroads of capillarisation and liver fibrosis

Liver fibrosis represents a serious worldwide health issue with a prevalence of around 5% in general populations.1 The most ...
Gut

Tryptophan depletion generates hyper-reactive portal neutrophils in alcoholic liver disease

Background Neutrophils guarantee a prompt and robust host response to pathogens. Yet, overshooting neutrophil activation ...
gut.bmj

Targeting ADAR1-mediated RNA editing inhibits hepatic stellate cell activation and liver fibrosis by enhancing HSC-intrinsic innate immunity

Background The pathogenesis of liver fibrosis centres on the activation of hepatic stellate cells (HSCs). Adenosine-to-inosine RNA editing, primarily catalysed by adenosine deaminase acting on RNA1 ...
gut.bmj

Pathological tau propagation from the brain to the colon via the vagal efferent pathway in Alzheimer’s disease

Background Alzheimer’s disease (AD) is a neurodegenerative disorder marked by the accumulation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles, leading to cognitive decline. Recent research ...
gut.bmj

Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts

1 Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, ...
gut.bmj

Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives

Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and ...
gut.bmj

Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians

12 Liver Clinic, Toronto Western & General Hospital, University Health Network, Toronto, Ontario, Canada Correspondence to Professor H L A Janssen, University of Toronto & Erasmus University Rotterdam ...
gut.bmj

Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder

Correspondence to Professor Siew C Ng, Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong; siewchienng{at}cuhk.edu.hk; Dr Ruth Chan, Applied Biology and Chemical ...
gut.bmj

Optimal age to discontinue long-term surveillance of intraductal papillary mucinous neoplasms: comparative cost-effectiveness of surveillance by age

3 Graduate School of Public Health, St Luke’s International University, Tokyo, Japan Objective Current guidelines recommend long-term image-based surveillance for patients with low-risk intraductal ...
gut.bmj

Argon plasma coagulation therapy for ablation of Barrett’s oesophagus

Endoscopic thermoablation with argon plasma coagulation (APC) for Barrett’s oesophagus is most effective for shorter segments but “buried” glands do occur. APC should remain in the area of ...
gut.bmj

Synergistic association of sodium-glucose cotransporter-2 inhibitor and metformin on liver and non-liver complications in patients with type 2 diabetes mellitus and metabolic ...

Objective Type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease (diabetic MASLD) frequently coexist and worsen liver and non-liver outcomes, but effective ...
gut.bmj

Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis

Objective To compare efficacy of pharmacotherapies for chronic idiopathic constipation (CIC) based on comparisons to placebo using Bayesian network meta-analysis. Data sources We conducted searches ...