How does a gene, which consists of a string of DNA hidden in a cell's nucleus, know when it should express itself? How does this gene cause the production of a string of amino acids called a protein?

In eukaryotes, the tight or loose packaging of the genes in chromatin (DNA plus specific proteins) can control whether the genes can be expressed to form their encoded product. Chromatin is usually ...

Gene regulation is the process by which cells control the expression of their genes, determining when, where, and to what extent each gene is expressed. It is a fundamental mechanism that allows cells ...

KYOTO – An international team of researchers has taken an important step toward understanding how gene expression is controlled across the human genome. A new study has comprehensively analyzed ...

Transcription by Pol II is dependent on a number of multi-subunit complexes including TFIID, a general transcription factor complex, and SAGA. Both deliver the TATA-box binding protein (TBP) to ...

The central focus of exploring regulatory elements in mRNA has been on sequence-specific RNA-binding proteins (RBPs) that influence mRNA stability, translation, and splicing. On the other hand, some ...

In biology classrooms, we often learn that genes are transcribed into mRNA, which is then translated into proteins—a tidy, linear process. But gene expression in living cells is far more intricate, ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...