Osaka, Japan - BRCA1, a protein that is well-known for its role in hereditary breast cancer, is an important part of the cellular system that repairs double-strand DNA breaks. Now, researchers from ...

KANSAS CITY, MO. (Dec. 16, 2004) - Thomas Kusch, Ph.D., a Senior Research Associate at the Stowers Institute working with Investigator Jerry Workman, Ph.D., has identified a histone-modifying complex ...

One of the hallmarks of DNA damage is the rapid spreading of phosphorylated histone H2A (γ-H2AX) around a DNA double-strand break (DSB). In the budding yeast Saccharomyces cerevisiae, nearly all H2A ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...

Zhi “Zack” Zheng is a member of molecular biologist Scott Keeney's lab. Zhi “Zack” Zheng, who is scheduled to receive his PhD from the Gerstner Sloan Kettering Graduate School of Biomedical Sciences ...

Divya Ramalingam Iyer, Naoya Harada, Connor Clairmont, Lige Jiang, David Martignetti, Huy Nguyen, Yizhou Joseph He, Dipanjan Chowdhury, Alan D. D’Andrea Proceedings of the National Academy of Sciences ...

EAST LANSING, Mich. (WLNS) — Researchers at Michigan State University’s College of Veterinary Medicine have made a discovery that could potentially impact gene editing strategies, among other things.

Structure Maintenance of Chromosome (SMC) complexes are central to chromosome segregation, compaction and DNA repair, thereby impacting on gene expression and regulation. SMC family members that ...

New work shows that neurons and other brain cells use DNA double-strand breaks, often associated with cancer, neurodegeneration and aging, to quickly express genes related to learning and memory.

Experimentation may be what first comes to mind when one contemplates the process of scientific research, but sometimes the best way to understand a system is to simply observe it in its native state.