Single-cell RNA-sequencing (scRNA-seq) technologies offer the opportunity to understand regulatory mechanisms at single-cell resolution. Gene regulatory networks (GRNs) provide a crucial blueprint of ...

"Our findings open avenues for biomarkers of therapy response and acquired drug resistance to help guide clinical decisions in individual patients with metastatic prostate cancer throughout the course ...

Researchers at Memorial Sloan Kettering Cancer Center (MSK) have developed a new open-source computational method, dubbed Spectra, which improves the analysis of single-cell transcriptomic data. By ...

Extracellular vesicles shed by prostate cancer cells to the bloodstream contain tumor-derived material that can be used as biomarkers of therapy response and resistance in patients with metastatic ...