For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...

The three pathways of activation all generate homologous variants of the protease C3-convertase. The classical complement pathway typically requires antigen—antibody complexes (immune complexes) for ...

Decades after the first report of a complement-activating factor in the serum of some people with chronic glomerulonephritis, its causal role in the disease is still debated. In a new study, mice ...